Chordotonal neuron dendrite iav9/3/2023 ![]() ![]() ![]() The embryonic PNS of Drosophila melanogaster is composed of different types of sensory neurons, which are divided into Type I - neurons with single dendrites, and Type II - multi-dendritic neurons. In this study, we are examining more closely the role of slit ( sli), and possible Slit-Robo signaling in the embryonic peripheral nervous system (PNS). For example, the Slit-Robo signaling pathways was found to be required for proper crossing of commissural axons in the central nervous system (CNS) in Drosophila. The fruit fly Drosophila melanogaster is a well-known model system for studying many of the fundamental aspects of neural development, including neuron-glia interactions, and the mechanisms and signaling pathways necessary for axon guidance. Even with all this information on the multitude of glial cell functions, we still have much to learn about how specific glial cells coordinate with neurons in the formation of the nervous system. It is known that glial cells ensheath axons and function to drive nerve formation, provide trophic support for neuronal survival, provide guidance during axon pathfinding, and modulate dendrite morphology. Proper development of the nervous system requires coordination between these two cell types. The nervous system is made up of neurons and glial cells. This study sheds light on the role of Slit-Robo signaling in sensory neuron development. Additionally, we demonstrate that the scolopale, cap and attachment cells follow the mis-migrated lch5 neurons in sli mutants, while the ventral stretching of the ligament cells seems to be independent of the lch5 neurons. We further show that mutations in the Sli receptors Robo and Robo2 also display similar defects as loss of sli, suggesting a role for Slit-Robo signaling in lch5 migration and positioning. We show here that the extracellular ligand sli is required for the proper ventral migration and morphology of the lch5 neurons. During embryogenesis, the lch5 neurons go through a rotation and ventral migration to reach their final position in the lateral region of the abdomen. The lateral chordotonal organs (lch5) of the Drosophila peripheral nervous system (PNS) are composed of five sensory neurons surrounded by four different glial cells, scolopale cells, cap cells, attachment cells and ligament cells. ![]() Both types of cells are receiving multiple guidance cues to guide the neurons and glial cells to their proper final position. Neurons and glial cells coordinate with each other in many different aspects of nervous system development. ![]()
0 Comments
Leave a Reply.AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |